Document Detail

Gastrin in the human fetus. Distribution and molecular forms of gastrin in the antro-pyloric gland area, duodenum and pancreas.
MedLine Citation:
PMID:  339325     Owner:  NLM     Status:  MEDLINE    
The ontogeny of human fetal gastrin has been investigated by immunocytochemistry and radioimmunochemistry. Gastrin and gastrin cells are shown to appear later in the antral than in the duodenal mucosa. At the ages studied (11--22 weeks of gestation) pancreatic gastrin could not be detected. Gastrin component III was found to predominate in the antrum, whereas component II was quantitatively very important in the duodenum. Circumstantial evidence suggests that fetal gastrin is delivered to the blood, and that it may exert trophic functions in the fetus.
L I Larsson; J F Rehfeld; N Goltermann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  12     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2010-02-23    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  869-72     Citation Subset:  IM    
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MeSH Terms
Duodenum / cytology,  embryology*
Fetus / physiology*
Fluorescent Antibody Technique
Gastric Mucosa / cytology,  embryology
Gastrins / analysis*
Gestational Age
Intestinal Mucosa / cytology,  embryology*
Pancreas / cytology,  embryology*
Pyloric Antrum / cytology,  embryology*
Reg. No./Substance:

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