| Gastrin cell hyperplasia in rats with chronic antral stimulation. | |
MedLine Citation:
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PMID: 1090478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats surgically prepared with the antrum transposed onto the colon were compared with suitable control rats, to investigate whether chronic antral stimulation modifies gastrin cell and other endocrine cell populations. Gastrin cell and argyrophil cell density per unit area were studied in antrum using a quantitative method after staining by immunofluorescence and Grimelius argyrophily, respectively. Both gastrin cells and argyrophil cells increased significantly in density per unit area after antrocolic transposition (P smaller than 0.001). The augmentation of gastrin cells per glandular tube (78%) was also significant (P smaller than 0.001). Electron-microscopic observations confirmed these results. On the other hand, in each group, the topographic distribution of the two categories of cells was different, and the number of gastrin cells was statistically greater than that of the argyrophil cells. Thus, it appeared evident that gastrin cells were not argyrophilic. Several hypotheses to explain the mechanism of this hyperplasia of endocrine cells are discussed. It is concluded that the increase in the gastrin cell density could be one possible explanation for the hypergastrinemia observed in the antrocolic transposition model. |
Authors:
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T Lehy; N Voillemot; M Dubrasquet; F Dufougeray |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 68 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-06-02 Completed Date: 1975-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 71-82 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Colon / surgery Feedback Fluorescent Antibody Technique Gastric Juice / metabolism, secretion Gastric Mucosa / pathology* Gastrins / blood, secretion Hyperplasia / pathology Immune Sera Male Microscopy, Electron Pyloric Antrum / pathology, surgery* Rabbits / immunology Rats Silver |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Immune Sera; 7440-22-4/Silver |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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