Document Detail

Gastrin cell hyperplasia in rats with chronic antral stimulation.
MedLine Citation:
PMID:  1090478     Owner:  NLM     Status:  MEDLINE    
Rats surgically prepared with the antrum transposed onto the colon were compared with suitable control rats, to investigate whether chronic antral stimulation modifies gastrin cell and other endocrine cell populations. Gastrin cell and argyrophil cell density per unit area were studied in antrum using a quantitative method after staining by immunofluorescence and Grimelius argyrophily, respectively. Both gastrin cells and argyrophil cells increased significantly in density per unit area after antrocolic transposition (P smaller than 0.001). The augmentation of gastrin cells per glandular tube (78%) was also significant (P smaller than 0.001). Electron-microscopic observations confirmed these results. On the other hand, in each group, the topographic distribution of the two categories of cells was different, and the number of gastrin cells was statistically greater than that of the argyrophil cells. Thus, it appeared evident that gastrin cells were not argyrophilic. Several hypotheses to explain the mechanism of this hyperplasia of endocrine cells are discussed. It is concluded that the increase in the gastrin cell density could be one possible explanation for the hypergastrinemia observed in the antrocolic transposition model.
T Lehy; N Voillemot; M Dubrasquet; F Dufougeray
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  68     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-82     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Count
Colon / surgery
Fluorescent Antibody Technique
Gastric Juice / metabolism,  secretion
Gastric Mucosa / pathology*
Gastrins / blood,  secretion
Hyperplasia / pathology
Immune Sera
Microscopy, Electron
Pyloric Antrum / pathology,  surgery*
Rabbits / immunology
Reg. No./Substance:
0/Gastrins; 0/Immune Sera; 7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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