Document Detail


Gastrin Treatment Stimulates {beta}-Cell Regeneration and Improves Glucose Tolerance in 95% Pancreatectomized Rats.
MedLine Citation:
PMID:  21558313     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes.
Authors:
Noèlia Téllez; Géraldine Joanny; Jéssica Escoriza; Marina Vilaseca; Eduard Montanya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-10
Journal Detail:
Title:  Endocrinology     Volume:  -     ISSN:  1945-7170     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Diabetes and Experimental Endocrinology (N.T., G.J., J.E., M.V., E.M.), Department of Clinical Sciences, University of Barcelona; Institut d'Investigacions Biomèdiques de Bellvitge, Institut d'Investigacions Biomèdiques de Bellvitge (N.T., G.J., J.E., M.V., E.M.), CIBER de Diabetes y Enfermedades Metabólicas Asociadas, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) (N.T., G.J., J.E., M.V., E.M.), Endocrine Unit (J.E., E.M.), Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
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