| Gastrin: an acid-releasing, proliferative and immunomodulatory peptide? | |
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MedLine Citation:
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PMID: 20380639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action. |
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Authors:
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Sara Calatayud; Angeles Alvarez; Víctor M Víctor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 10 ISSN: 1875-5607 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 8-19 Citation Subset: IM |
Affiliation:
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Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia, Avd. Blasco Ibáñez 15, Valencia, Spain. sara.calatayud@uv.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation* Gastric Acid / secretion* Gastrin-Secreting Cells / drug effects, physiology Gastrinoma / physiopathology Gastrins / genetics, metabolism, physiology*, secretion Gastritis / physiopathology Humans Immunomodulation* Protein Precursors / genetics, metabolism Receptors, Cholecystokinin / antagonists & inhibitors, physiology Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Protein Precursors; 0/Receptors, Cholecystokinin; 81690-22-4/preprogastrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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