| Gastric ulcers and risk for cancer. Is follow-up necessary for all gastric ulcers? | |
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MedLine Citation:
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PMID: 15311724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the accuracy of initial endoscopy combined with histology and to define whether there is a point in following-up all gastric ulcers until complete healing. We have studied all patients with gastric ulcers documented at endoscopy during a 6-year period. Ulcers were macroscopically characterised as benign or suspicious for malignancy, and biopsies were taken. A follow-up endoscopy and histology was performed 4-6 weeks and 3 months after an anti-ulcer treatment. Resistant ulcers were treated surgically. All patients were followed-up clinically and endoscopically for a year after complete ulcer healing. 802 patients with gastric ulcers were enrolled. At initial endoscopy, 732 ulcers (91.3%) were macroscopically characterised as benign and 70 ulcers (8.7%) as suspicious for malignancy. In the group of endoscopically benign ulcers, only one (0.1%) had malignancy detected by biopsy in the first examination. None of these ulcers turned out to be malignant on subsequent examinations. From the suspicious for malignancy ulcers, 20 (28.6%) were proven to be malignant. Endoscopy may recognise with great accuracy benign ulcers, but it overestimates the malignant ones. The cost-benefit of serial follow-up endoscopies should be re-evaluated in ulcers that appear benign, and biopsies are negative at the initial examination. |
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Authors:
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K C Thomopoulos; M P Melachrinou; K P Mimidis; E C Katsakoulis; V G Margaritis; C E Vagianos; V N Nikolopoulou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical practice Volume: 58 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-08-17 Completed Date: 2004-11-10 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 675-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Rion University Hospital, Patras, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Diagnosis, Differential Endoscopy, Gastrointestinal / methods Female Follow-Up Studies Humans Male Middle Aged Retrospective Studies Risk Factors Stomach Neoplasms / etiology*, pathology Stomach Ulcer / complications*, pathology |
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