Document Detail

Gastric tonometry and intramucosal pH--theoretical principles and clinical application.
MedLine Citation:
PMID:  11043915     Owner:  NLM     Status:  MEDLINE    
Gastric or intestinal luminal tonometry is a method for monitoring critically ill patients. It offers an index of the adequacy of aerobic metabolism in a tissue that is particularly sensitive to alterations in its perfusion and oxygenation: the gut mucosa. It is based on the measuring the increase in tissue CO2 production that accompanies anaerobic metabolism. The method simply consists of a balloon in the stomach, which measures intramucosal pCO2. From this measurement and from the arterial bicarbonate concentration gastric intramucosal pH (pHi) can be calculated, assuming that bicarbonate concentration in the gastric mucosal tissue is in equilibrium with systemic arterial bicarbonate. Despite possible clinical benefit from the measurement and the therapy of low pHi values in critically ill patients, the theoretical, experimental and pathophysiological implications for the monitoring of intramucosal acidosis in the gut are not yet fully understood. There are still some open methodological questions crucial for further clinical interpretation.
V Cerný; K Cvachovec
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  49     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-19     Completed Date:  2001-02-15     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  289-97     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, Charles University, Faculty Hospital Hradec Králové, Czech Republic.
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MeSH Terms
Anoxia / diagnosis*,  metabolism
Bicarbonates / analysis
Carbon Dioxide / analysis
Critical Care / methods*
Gastric Mucosa / blood supply,  metabolism*
Hydrogen-Ion Concentration*
Splanchnic Circulation / physiology
Tonometry, Ocular / methods*
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

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