| Gastric tonometry and intramucosal pH--theoretical principles and clinical application. | |
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MedLine Citation:
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PMID: 11043915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric or intestinal luminal tonometry is a method for monitoring critically ill patients. It offers an index of the adequacy of aerobic metabolism in a tissue that is particularly sensitive to alterations in its perfusion and oxygenation: the gut mucosa. It is based on the measuring the increase in tissue CO2 production that accompanies anaerobic metabolism. The method simply consists of a balloon in the stomach, which measures intramucosal pCO2. From this measurement and from the arterial bicarbonate concentration gastric intramucosal pH (pHi) can be calculated, assuming that bicarbonate concentration in the gastric mucosal tissue is in equilibrium with systemic arterial bicarbonate. Despite possible clinical benefit from the measurement and the therapy of low pHi values in critically ill patients, the theoretical, experimental and pathophysiological implications for the monitoring of intramucosal acidosis in the gut are not yet fully understood. There are still some open methodological questions crucial for further clinical interpretation. |
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Authors:
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V Cerný; K Cvachovec |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 49 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-19 Completed Date: 2001-02-15 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 289-97 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, Charles University, Faculty Hospital Hradec Králové, Czech Republic. cernyvla@fnhk.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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diagnosis*,
metabolism Bicarbonates / analysis Carbon Dioxide / analysis Critical Care / methods* Gastric Mucosa / blood supply, metabolism* Humans Hydrogen-Ion Concentration* Splanchnic Circulation / physiology Tonometry, Ocular / methods* |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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