Document Detail

Gastric secretion--from Pavlov's nervism to Popielski's histamine as direct secretagogue of oxyntic glands.
MedLine Citation:
PMID:  15075464     Owner:  NLM     Status:  MEDLINE    
Gastric acid and pepsin secretions result from the interplay of neurohormonal factors with stimulatory and inhibitory actions on oxyntic glands. At the turn of XIX century, the notion of nervism or entire neural control of digestive functions, developed by Pavlov prevailed. However, in the second part of XX century, hormonal control has been thought to play a major role in the mechanism of gastric secretion, especially gastrin, which was isolated and synthesized in 1964 by Gregory. Polish traces in gastroenterological history started with the discovery of histamine, a non-nervous and non-gastrin compound in oxyntic mucosa by L. Popielski in 1916, who found that this amine is the most potent and direct stimulant of gastric acid secretion. This histamine concept was supported by leading American gastroenterologists such as A.C. Ivy, championed later by C.F. Code, and clinically applied for testing gastric secretion by K. Kowalewski. Recently, it received a strong support from pharmacological research when J. Black designed H(2)-receptors antagonists, which were first discovered by M.I. Grossman and S.J. Konturek to inhibit not only histamine-, but also meal- and vagally-induced gastric acid secretion, thus reinforcing the notion of the crucial significance of histamine in the control of gastric secretion as the final common chemostimulator. In conclusion, Polish traces appear to be substantial in gastric history due: 1) to discovery by Popielski that histamine is a major, direct stimulus of gastric secretion; 2) to clinical application of this agent by Kowalewski in testing maximal gastric secretory activity; and 3) to clinical use of histamine H(2)-antagonists in control of gastric acid secretion and treatment of peptic ulcers.
S J Konturek
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  54 Suppl 3     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2008-01-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  43-68     Citation Subset:  IM    
Department of Physiology, Jagiellonian University Medical College, Krakow, Poland.
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MeSH Terms
Gastric Juice / secretion*
Gastric Mucosa / secretion*
Histamine / history*
Histamine Release / physiology*
History, 19th Century
History, 20th Century
Neurons / physiology*
Parietal Cells, Gastric / secretion
Reg. No./Substance:
Personal Name Subject
Personal Name Subject:
L Popielski; Ivan Petrovich Pavlov

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