Document Detail


Gastric proteases in the human infant.
MedLine Citation:
PMID:  3118972     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The electrophoretic mobilities of proteases present in gastric juice taken within 10 h of birth from 5 healthy, premature infants were compared with calf chymosin, pig pepsin A and human adult gastric juice. The juice from 2 infants contained predominantly a chymosin-like enzyme, another had almost exclusively pepsins similar to those of the adult juice, while the other two contained a mixture of both. The pepsins consisted of two elements, probably pepsin A (EC 3.4.23.1), and pepsin C (EC 3.4.23.3). Single radial immunodiffusion gave a definite reaction to calf anti-chymosin serum in five samples taken from a further 17 infants. These results indicate that some human infants secrete chymosin. The reaction in the immunodiffusion assay indicated a much lower enzyme activity than that implied from electrophoretic separations. It is suggested that species differences resulted in poor cross-reactivity of the antiserum.
Authors:
M J Henschel; M J Newport; V Parmar
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  52     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-19     Completed Date:  1988-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  268-72     Citation Subset:  IM    
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, Berks, UK.
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MeSH Terms
Descriptor/Qualifier:
Chymosin / metabolism
Electrophoresis, Agar Gel
Gastric Juice / enzymology*
Gestational Age
Humans
Immunodiffusion
Infant, Newborn
Pepsin A / metabolism
Peptide Hydrolases / metabolism*
Chemical
Reg. No./Substance:
EC 3.4.-/Peptide Hydrolases; EC 3.4.23.1/Pepsin A; EC 3.4.23.3/gastricsin; EC 3.4.23.4/Chymosin

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