Document Detail

Gastric pH and microflora of normal and diarrhoeic infants.
MedLine Citation:
PMID:  274     Owner:  NLM     Status:  MEDLINE    
The microflora and pH of gastric contents were determined in breast-fed and in bottle-fed normal infants, in well nourished infants with acute diarrhoea and in infants with chronic diarrhoea and protein-calorie malnutrition. The last group of infants was reevaluated after recovery from diarrhoea and protein-calorie malnutrition. A bactericidal pH effect below 2-5 was observed. Bottle-fed controls had low pH values and low bacterial concentrations, whereas infants with chronic diarrhoea and protein-calorie malnutrition had high pH values and bacterial overgrowth, essentially of Gram-negative bacilli. After recovery, the only remaining alteration was the frequent isolation of yeast-like fungi in low concentrations. Infants with acute diarrhoea, except for the isolation more frequently of yeast-like fungi, presented no alterations; this seems to indicate that pH alterations and Gram-negative bacilli overgrowth occurred during the evolution of the disease to a chronic state. Breast-fed normal infants had hydrogen-ion concentrations similar to those of the chronic diarrhoea group, but without Gram-negative bacilli overgrowth, suggesting that other factors, besides pH, regulate bacterial growth in the gastric contents of these groups of infants.
H V Maffei; F J Nóbrega
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gut     Volume:  16     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  719-26     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Bacteria / isolation & purification*
Breast Feeding
Candida albicans / isolation & purification
Chronic Disease
Diarrhea, Infantile / microbiology*
Enterobacteriaceae / isolation & purification
Gastric Juice / secretion*
Hydrogen-Ion Concentration
Pharynx / microbiology
Protein-Energy Malnutrition / microbiology
Pseudomonas / isolation & purification
Staphylococcus / isolation & purification
Stomach / microbiology*
Streptococcus / isolation & purification

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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