Document Detail

Gastric muscularis as a urinary sphincter.
MedLine Citation:
PMID:  8116128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the ability of gastric muscularis to act as a urinary sphincter in a rat model system. METHODS: Fourteen Long-Evans rats had an ileal conduit constructed joining the bladder to the ventral skin, creating urinary incontinence. A segment of gastric muscle maintained on its vascular pedicle was encircled around the conduit. The first 7 animals (group A) had both conduit and sphincter constructed simultaneously, whereas the remaining 7 animals had the conduit constructed first, followed by a two-week period of observation, after which gastric sphincters were added (group B). All animals were observed for urine leakage via the cutaneous stoma. At two weeks after sphincter placement, all animals underwent surgical exploration, pressure profilometry of the conduit, and histologic examination of the sphincter zone. RESULTS: Pressure profilometry demonstrated elevated pressures in the sphincter zone relative to baseline pressures in the conduit of all animals (group A: mean baseline, 4.8 cm water, mean maximum, 20.6 cm water; group B: mean baseline, 5.2 cm water, mean maximum, 18.1 cm water). At exploration, no intra-abdominal complications were noted in 13 of 14 animals. All conduits were easily catheterizeable and were found to be continent after they had been filled to capacity. The ileum and gastric segments were histologically found to be viable with no evidence of necrosis or ischemia. CONCLUSIONS: These preliminary results suggest that gastric muscularis may be a potential substitute urinary sphincter in the management of sphincteric urinary incontinence.
A G Aprikian; Z Guan; K Nielson; G Kiruluta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Urology     Volume:  43     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Department of Surgery, Montreal Children's Hospital, McGill University, Quebec, Canada.
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MeSH Terms
Gastrectomy / methods
Gastric Mucosa / surgery*
Muscle, Smooth / surgery*
Rats, Inbred Strains
Surgical Flaps / methods
Suture Techniques
Urinary Incontinence / surgery*
Urinary Reservoirs, Continent / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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