| Gastric mucosal energy metabolism and intracellular mucin content changes in patients with liver cirrhosis. | |
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MedLine Citation:
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PMID: 8713706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biopsy samples from patients with liver cirrhosis were investigated for changes in gastric mucosal energy metabolism and intracellular mucin content using high performance liquid chromatography and an image analysing system. The test group consisted of eight non-cirrhotic patients with endoscopically normal mucosa (controls) and eight cirrhotic patients with oesophageal varices. The amount of ATP, energy charge level and intracellular mucin content were all significantly decreased in cirrhotic patients when compared with those of the controls. The decrease in energy charge also correlated well with the decrease in intracellular mucin content in the gastric mucosa. The results indicate that gastric mucosal energy metabolism is impaired in cirrhotic patients concomitantly with a decrease in the intracellular mucin content in the gastric mucosa. These changes may weaken defensive mechanisms against acid and NSAID, resulting in gastric mucosal injury in cirrhotic patients. |
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Authors:
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S Kawano; H Tanimura; S Tsuji; Y Takei; K Nagano; T Kashiwagi; H Fusamoto; T Kamada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 11 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 380-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Osaka University School of Medicine, Suita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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metabolism Adenosine Monophosphate / metabolism Energy Metabolism* Gastric Mucosa / metabolism* Humans Intracellular Membranes / metabolism* Liver Cirrhosis / metabolism* Middle Aged Mucins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Mucins; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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