Document Detail


Gastric motor disturbances in patients with idiopathic rapid gastric emptying.
MedLine Citation:
PMID:  21470342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The mechanisms of 'idiopathic' rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying.
METHODS: Fasting and postprandial (300kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time-series of gastric cross-sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
KEY RESULTS: While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P=0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3cpm in healthy people and patients. Compared with controls (0.32±0.04, Mean±SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2-14.0) in patients with rapid (0.48±0.06), but not normal gastric emptying (0.20±0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
CONCLUSIONS & INFERENCES: MRI provides a non-invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia.
Authors:
A E Bharucha; A Manduca; D S Lake; J Fidler; P Edwards; R C Grimm; A R Zinsmeister; S J Riederer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-06
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  23     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-17     Completed Date:  2011-12-07     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  617-e252     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. bharucha.adil@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Dyspepsia / pathology,  physiopathology*
Female
Gastric Emptying / physiology*
Gastrointestinal Motility / physiology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Muscle Contraction / physiology
Organ Size
Postprandial Period
Regression Analysis
Stomach / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
P01 DK068055-06A1/DK/NIDDK NIH HHS; P01DK68055/DK/NIDDK NIH HHS
Comments/Corrections

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