| Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism. | |
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MedLine Citation:
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PMID: 22180845 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The obesity epidemic imposes a significant health burden on human beings. Current understanding of the mechanisms underlying the development of obesity is incomplete and contemporary treatment is often ineffective. Gastrointestinal hormones are important regulators of food intake and energy metabolism. Previous studies indicate that the mammalian target of rapamycin signaling pathway in the gastric mucosa is crucially involved in fuel sensing in the gastrointestinal tract and plays a critical role in the coordination of nutrient availability and ingestive behavior via the production of gastric hormones. As an important component of the brain-gut axis regulating food intake and energy homeostasis, energy sensing in the gastrointestinal tract may provide a novel insight into our understanding of the precise coordination between the organism and cellular energy state. |
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Authors:
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Ge-Yang Xu; Yin Li; Wei-Zhen Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastrointestinal pathophysiology Volume: 2 ISSN: 2150-5330 ISO Abbreviation: World J Gastrointest Pathophysiol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101547471 Medline TA: World J Gastrointest Pathophysiol Country: China |
Other Details:
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Languages: eng Pagination: 109-13 Citation Subset: - |
Affiliation:
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Ge-Yang Xu, Yin Li, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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