Document Detail

Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism.
MedLine Citation:
PMID:  22180845     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The obesity epidemic imposes a significant health burden on human beings. Current understanding of the mechanisms underlying the development of obesity is incomplete and contemporary treatment is often ineffective. Gastrointestinal hormones are important regulators of food intake and energy metabolism. Previous studies indicate that the mammalian target of rapamycin signaling pathway in the gastric mucosa is crucially involved in fuel sensing in the gastrointestinal tract and plays a critical role in the coordination of nutrient availability and ingestive behavior via the production of gastric hormones. As an important component of the brain-gut axis regulating food intake and energy homeostasis, energy sensing in the gastrointestinal tract may provide a novel insight into our understanding of the precise coordination between the organism and cellular energy state.
Ge-Yang Xu; Yin Li; Wei-Zhen Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastrointestinal pathophysiology     Volume:  2     ISSN:  2150-5330     ISO Abbreviation:  World J Gastrointest Pathophysiol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-08-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101547471     Medline TA:  World J Gastrointest Pathophysiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  -    
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
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