| Gastric lymphoepithelioma-like carcinoma associated with Epstein-Barr virus proved by in situ hybridization study: a case report. | |
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MedLine Citation:
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PMID: 7982142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Undifferentiated gastric carcinoma with prominent lymphoid infiltration and a striking resemblance to nasopharyngeal lymphoepithelioma has rarely been reported. Recently, the Epstein-Barr virus (EBV) genome has been demonstrated in some cases of gastric carcinoma with a morphology similar to undifferentiated nasopharyngeal carcinoma (NPC). One such case has been identified here by immunohistochemistry; it was explored for the EBV genome by RNA in situ hybridization (ISH) with an EBERs (Epstein-Barr virus encoded RNAs) probe. EBV RNAs were detected uniformly in the carcinoma cells or adjacent dysplasia epithelium, but were not present in the related lymphoid infiltration or in normal gastric mucosa. These findings add to the growing body of evidence suggesting the strong association of EBV with gastric lympho-epithelioma-like carcinoma (LELC), and also indicate that a latent EBV infection may play a role in undifferentiated epithelial cells. |
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Authors:
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H J Harn; L I Ho; H S Lee; W H Lee |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed Volume: 54 ISSN: 0578-1337 ISO Abbreviation: Zhonghua Yi Xue Za Zhi (Taipei) Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-01-04 Completed Date: 1995-01-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0005327 Medline TA: Zhonghua Yi Xue Za Zhi (Taipei) Country: TAIWAN |
Other Details:
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Languages: eng Pagination: 282-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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virology* Female Herpesvirus 4, Human / genetics, isolation & purification* Humans In Situ Hybridization Middle Aged RNA, Viral / analysis Stomach Neoplasms / virology* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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