Document Detail


Gastric luminal epidermal growth factor is affected by diet.
MedLine Citation:
PMID:  15662994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Diet is an area of major interest to those investigating the causes of cancer of the oesophagus in the Transkei. This study looked at the associations between intragastric epidermal growth factor level, diet and intragastric pH.
SETTING AND SUBJECTS: A dietary survey was co-ordinated with studies of gastric luminal epidermal growth factor and gastric fluid pH in 120 rural Transkeians.
RESULTS: Gastric fluid epidermal growth factor was associated with low dietary intake of animal products (p = 0.002) and vegetables (p = 0.026). There was no association with pH.
CONCLUSION: A dietary subgroup has been identified in the Transkei population with high levels of epidermal growth factor in the upper gastrointestinal lumen. This adds to previously demonstrated diet-related changes in the upper gastrointestinal tract in Transkei. These changes may affect the disease pattern of the population.
Authors:
J E Iputo; A M Sammon; L Mapele; K O Awotedu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  94     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-02-03     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  969-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cocarcinogenesis
Dairy Products
Diet / adverse effects*
Diet Surveys
Epidermal Growth Factor / analysis*,  physiology
Esophageal Neoplasms / epidemiology,  etiology*
Fruit
Gastric Acidity Determination
Gastric Juice / chemistry*,  physiology
Gastric Mucosa / chemistry*,  physiology
Humans
Hydrogen-Ion Concentration
Meat
Metabolic Clearance Rate
Pepsin A / physiology
Poverty / statistics & numerical data
Questionnaires
Radioimmunoassay
Rural Health / statistics & numerical data
South Africa / epidemiology
Vegetables
Chemical
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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