Document Detail

Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents.
MedLine Citation:
PMID:  8238459     Owner:  NLM     Status:  MEDLINE    
Both gastric preloads and exogenous cholecystokinin (CCK) administration inhibit food intake, and combinations of preloads and CCK suppress feeding to a greater degree than either stimulus delivered alone. A role for the vagus nerve in mediating CCK's inhibition of food intake has been proposed, and gastric vagal afferent fibers respond to both gastric loads and local CCK infusions. To examine whether combined load and CCK stimuli may synergistically augment gastric neural afferent activity at the level of the peripheral vagus, we have examined the gastric vagal afferent responses (n = 8) to a range of gastric saline loads (1, 2, and 3 ml) and exogenous close celiac arterial CCK (10 and 100 pmol) when administered alone or in combination. Gastric loads ineffective in eliciting a significant increase in vagal afferent activity when administered alone became effective when combined with doses of CCK that were subthreshold for the production of a vagal afferent response. Gastric loads that alone were effective in producing a significant vagal afferent response yielded an even greater response when administered in combination with both subthreshold and suprathreshold doses of CCK. These data demonstrate that, in rats, signals produced by combined gastric load and exogenous CCK administration are integrated peripherally and interact synergistically. These results suggest that signals arising from the vagus may provide sufficient information for the synergistic inhibition of food intake produced by combinations of gastric loads and exogenous CCK.
G J Schwartz; P R McHugh; T H Moran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-01     Completed Date:  1993-12-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R872-6     Citation Subset:  IM; S    
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
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MeSH Terms
Afferent Pathways / physiology
Celiac Artery
Cholecystokinin / pharmacology*
Dose-Response Relationship, Drug
Drug Synergism
Gastrointestinal Contents*
Injections, Intra-Arterial
Intubation, Gastrointestinal
Physical Stimulation
Rats, Sprague-Dawley
Sodium Chloride / pharmacology
Stimulation, Chemical
Stomach / innervation*
Vagus Nerve / physiology*
Grant Support
Reg. No./Substance:
7647-14-5/Sodium Chloride; 9011-97-6/Cholecystokinin

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