Document Detail

Gastric juice acidity in upper gastrointestinal diseases.
MedLine Citation:
PMID:  21086570     Owner:  NLM     Status:  MEDLINE    
AIM: To search the independent factors determining gastric juice acidity and to investigate the acidity of gastric juices in various benign and malignant upper gastrointestinal diseases.
METHODS: Fasting gastric juice acidity of 165 healthy subjects and 346 patients with esophageal ulcer (n = 21), gastric ulcer (n = 136), duodenal ulcer (n = 100) or gastric cancer (n = 89) were measured and compared. Additionally, gastric specimens were taken from the antrum and body for rapid urease test and histological examination.
RESULTS: Multivariate analysis revealed that bile stain of gastric juice, high acute inflammatory score of the corpus, and atrophy of the corpus were independent risk factors for the development of gastric hypoacidity with odds ratios of 3.1 (95% CI: 1.3-7.3), 3.1 (95% CI: 1.2-7.9) and 3.5 (95% CI: 1.3-9.2). Esophageal ulcer and duodenal ulcer patients had a lower pH level (1.9 and 2.1 vs 2.9, both P < 0.05) of gastric juices than healthy subjects. In contrast, gastric ulcer and gastric cancer patients had a higher pH level (3.4 and 6.6 vs 2.9, both P < 0.001) than healthy controls. Hypoacidity existed in 22%, 5%, 29%, 5% and 88% of healthy subjects, esophageal ulcer, gastric ulcer, duodenal ulcer and gastric cancer patients, respectively.
CONCLUSION: Bile reflux, atrophy and dense neutrophil infiltrate of the corpus are three independent factors determining the acidity of gastric juice.
Pei-Jung Lu; Ping-I Hsu; Chung-Hsuan Chen; Michael Hsiao; Wei-Chao Chang; Hui-Hwa Tseng; Kung-Hung Lin; Seng-Kee Chuah; Hui-Chun Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-04-08     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5496-501     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Atrophy / physiopathology
Bile Reflux / physiopathology
Case-Control Studies
Duodenal Ulcer / pathology,  physiopathology
Esophageal Diseases / pathology,  physiopathology
Gastric Juice / physiology*
Gastrointestinal Diseases / pathology*,  physiopathology*
Hydrogen-Ion Concentration
Middle Aged
Neutrophil Infiltration / physiology
Stomach Ulcer / pathology,  physiopathology
Ulcer / pathology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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