Document Detail


Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat.
MedLine Citation:
PMID:  6359287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of gastric inhibitory polypeptide (GIP) on fatty acid incorporation into adipose tissue (FIAT) was studied in the rat on epididymal fat pads at concentrations amounting to 1, 2 and 4 ng/ml. Without insulin in the incubation medium, GIP induced a slight though significant FIAT decrease with a maximum of 9% for 2 ng/ml concentration. In the presence of rat insulin (100 microU/ml), it significantly enhanced the insulin-induced FIAT increase, that progressed from 106.4% of the basal value to 110.5% for 1 ng/ml concentration (P less than 0.025) and to 118.2% for 4 ng/ml concentration (P less than 0.0025). The existence of such a phenomenon as well as that of an hyperactive enteroinsular axis in obese subjects could represent two important factors in the development of obesity.
Authors:
B Beck; J P Max
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  7     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects,  metabolism*
Animals
Blood Glucose / analysis
Cholesterol / blood
Gastric Inhibitory Polypeptide / pharmacology*
Gastrointestinal Hormones / pharmacology*
Insulin / blood,  pharmacology*
Kinetics
Palmitic Acid
Palmitic Acids / metabolism*
Rats
Rats, Inbred Strains
Triglycerides / biosynthesis,  blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Gastrointestinal Hormones; 0/Palmitic Acids; 0/Triglycerides; 11061-68-0/Insulin; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; 59392-49-3/Gastric Inhibitory Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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