Document Detail


Gastric hepatoid adenocarcinoma with autophagy-related necrosis-like tumor cell death: report of a case.
MedLine Citation:
PMID:  16971355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of hepatoid adenocarcinoma of the stomach is presented. The characteristic features of the tumor are summarized on the basis of the authors' experience and the literature. Ultrastructural examination revealed patchy condensations of chromatin throughout the nucleus suggestive of necrosis-like programmed cell death (PCD). These nuclear alterations were associated with the occurrence of vacuoles and lipofuscins, conferring an autophagic phenotype to this PCD. Thus, the case reported here provides an example of autophagic-related necrosis-like PCD. Alternative PCDs are reviewed and their morphologic distinction is discussed.
Authors:
R A Caruso; F Basile; F Fedele; V Zuccalà; C Crisafulli; M G Fracassi; E Quattrocchi; A Venuti; V Fabiano
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrastructural pathology     Volume:  30     ISSN:  1521-0758     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-10-03     Revised Date:  2009-06-26    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Affiliation:
Departimento di Patologia Umana, Policlinico Universitario, Messina, Italy. Rosariocaruso@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology*,  physiopathology*
Aged
Autophagy*
Hepatocytes / pathology*
Humans
Male
Microscopy, Electron
Necrosis
Stomach Neoplasms / metabolism,  pathology*,  physiopathology*
alpha-Fetoproteins / biosynthesis
Chemical
Reg. No./Substance:
0/alpha-Fetoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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