| Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats. | |
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MedLine Citation:
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PMID: 17283234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The duration of breastfeeding has attracted much interest, as a prolonged period of breastfeeding has been shown to reduce the risk of developing obesity. The mechanism behind the reduced risk is, however, poorly understood. The novel hormone ghrelin augments appetite, promotes body weight increase and increases adiposity. The majority of circulating ghrelin emanates from endocrine cells in the oxyntic mucosa of the stomach. In newborn humans and rodents, the number of ghrelin cells is low after birth until weaning, when the cell population is greatly expanded. To date, information about the influence of weaning perturbations on ghrelin cell development is scarce. Therefore, we studied the effect of delayed weaning on gastric ghrelin expression and plasma ghrelin concentration. To this end, special food separator cages were used to prevent the pups from eating solid food, forcing them to drink milk up to 21 days of age. Gastric ghrelin expression was examined by immunocytochemistry and in situ hybridisation, and plasma concentrations were assessed by RIA. Our data showed that gastric ghrelin expression and plasma ghrelin concentration are maintained at a lower level by delayed weaning. We also found that the relation between gastric ghrelin expression and body weight was altered by delayed weaning. Thus, control rats displayed a positive correlation between ghrelin expression and body weight, while no such correlation was evident in animals with delayed weaning. We conclude that delayed weaning exerts a negative influence on ghrelin expression, and that the onset of solid food intake may trigger normal ghrelin expression. Therefore, we suggest that ghrelin may constitute a hormonal link between the duration of breastfeeding and body weight development. |
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Authors:
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Frida Fåk; Lennart Friis-Hansen; Björn Weström; Nils Wierup |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 192 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-06 Completed Date: 2007-04-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 345-52 Citation Subset: IM |
Affiliation:
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Department of cell and Organism biology, Lund University, Lund, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation Body Weight Female Ghrelin Immunohistochemistry / methods In Situ Hybridization / methods Microscopy, Fluorescence Peptide Hormones / blood, genetics, physiology* RNA, Messenger / analysis Radioimmunoassay Rats Rats, Sprague-Dawley Stomach / chemistry, cytology*, growth & development Time Factors Weaning* |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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