| Gastric fluid pH and volume in gynaecologic out-patients. Influences of cimetidine and cimetidine-sodium citrate combination. | |
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MedLine Citation:
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PMID: 11767426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighty consecutive ASA physical status 1 women scheduled for day-case gynaecological laparoscopy under general anaesthesia were randomly allocated during the pre-operative visit to receive one of four premedication regimes. Patients in group 1 received hydroxyzine 100 mg; patients in group 2 received hydroxyzine 100 mg and cimetidine 400 mg; patients in group 3 received hydroxyzine 100 mg and effervescent cimetidine (cimetidine 200 mg + sodium citrate 1.8 g). All were given orally in 30 ml of water, 90 min before anaesthetic induction. Patients in group 4 received effervescent cimetidine orally in 30 ml of water 5 min before anaesthetic induction. Following induction of anaesthesia, gastric pH and residual volume (phenol red dilution technique) were measured. Gastric pH was higher (P < 0.05) in groups 2, 3 and 4 (medians: 5.71, 4.84, 6.07, respectively) than in group 1 (2.18). No patient had a gastric pH < or = 2.5 in group 4 compared with 13/14 n group 1, 1/15 in group 2 and 2/14 in group 3 (P < 0.0001). Mean gastric volumes were higher (P < 0.05) in group 4 (30.4 +/- 23.2 ml) than in groups 1, 2 and 3 (11.8 +/- 6.4, 15.8 +/- 11.2, 17.2. +/- 24.4 ml, respectively). Nine of the 19 patients in group 4 had a volume higher than 25 ml. Only one patient in group 1 had both gastric pH < or = 2.5 and volume > or = 25 ml. The administration of effervescent cimetidine 5 min prior to anaesthetic induction seems to be an easy and effective method of decreasing the acidity of gastric contents in day surgery. |
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Authors:
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P Narchi; D Edouard; P Bourget; J Otz; I Cattaneo |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 10 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 1993 Sep |
Date Detail:
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Created Date: 2001-12-20 Completed Date: 2002-01-09 Revised Date: 2013-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 357-61 Citation Subset: IM |
Affiliation:
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Département d'Anesthésiologie, Université de Paris-Sud, Hôpital Antoine Béclère, 92141 Clamart, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General Anti-Ulcer Agents / pharmacology* Cimetidine / pharmacology* Citrates / pharmacology* Female Gastric Acid / physiology* Gynecologic Surgical Procedures Histamine H1 Antagonists / pharmacology Histamine H2 Antagonists / pharmacology Humans Hydrogen-Ion Concentration Hydroxyzine / pharmacology Laparoscopy Prospective Studies Stomach / anatomy & histology, drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Citrates; 0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 1Q73Q2JULR/sodium citrate; 51481-61-9/Cimetidine; 68-88-2/Hydroxyzine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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