Document Detail

Gastric fluid pH and volume in gynaecologic out-patients. Influences of cimetidine and cimetidine-sodium citrate combination.
MedLine Citation:
PMID:  11767426     Owner:  NLM     Status:  MEDLINE    
Eighty consecutive ASA physical status 1 women scheduled for day-case gynaecological laparoscopy under general anaesthesia were randomly allocated during the pre-operative visit to receive one of four premedication regimes. Patients in group 1 received hydroxyzine 100 mg; patients in group 2 received hydroxyzine 100 mg and cimetidine 400 mg; patients in group 3 received hydroxyzine 100 mg and effervescent cimetidine (cimetidine 200 mg + sodium citrate 1.8 g). All were given orally in 30 ml of water, 90 min before anaesthetic induction. Patients in group 4 received effervescent cimetidine orally in 30 ml of water 5 min before anaesthetic induction. Following induction of anaesthesia, gastric pH and residual volume (phenol red dilution technique) were measured. Gastric pH was higher (P < 0.05) in groups 2, 3 and 4 (medians: 5.71, 4.84, 6.07, respectively) than in group 1 (2.18). No patient had a gastric pH < or = 2.5 in group 4 compared with 13/14 n group 1, 1/15 in group 2 and 2/14 in group 3 (P < 0.0001). Mean gastric volumes were higher (P < 0.05) in group 4 (30.4 +/- 23.2 ml) than in groups 1, 2 and 3 (11.8 +/- 6.4, 15.8 +/- 11.2, 17.2. +/- 24.4 ml, respectively). Nine of the 19 patients in group 4 had a volume higher than 25 ml. Only one patient in group 1 had both gastric pH < or = 2.5 and volume > or = 25 ml. The administration of effervescent cimetidine 5 min prior to anaesthetic induction seems to be an easy and effective method of decreasing the acidity of gastric contents in day surgery.
P Narchi; D Edouard; P Bourget; J Otz; I Cattaneo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  10     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  1993 Sep 
Date Detail:
Created Date:  2001-12-20     Completed Date:  2002-01-09     Revised Date:  2013-04-04    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  IM    
Département d'Anesthésiologie, Université de Paris-Sud, Hôpital Antoine Béclère, 92141 Clamart, France.
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MeSH Terms
Anesthesia, General
Anti-Ulcer Agents / pharmacology*
Cimetidine / pharmacology*
Citrates / pharmacology*
Gastric Acid / physiology*
Gynecologic Surgical Procedures
Histamine H1 Antagonists / pharmacology
Histamine H2 Antagonists / pharmacology
Hydrogen-Ion Concentration
Hydroxyzine / pharmacology
Prospective Studies
Stomach / anatomy & histology,  drug effects*,  metabolism
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Citrates; 0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 1Q73Q2JULR/sodium citrate; 51481-61-9/Cimetidine; 68-88-2/Hydroxyzine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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