Document Detail

Gastric exocrine and endocrine secretion.
MedLine Citation:
PMID:  19726980     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review summarizes the last year's literature regarding the regulation and measurement of gastric exocrine and endocrine secretion. RECENT FINDINGS: Parietal cells, distributed along much of the length of the oxyntic glands, with highest density in the neck and base, secrete HCl as well as transforming growth factor-alpha, amphiregulin, heparin-binding epidermal growth factor-like growth factor, and sonic hedgehog. Acid facilitates the digestion of protein and absorption of iron, calcium, vitamin B(12) as well as prevents bacterial overgrowth, enteric infection, and possibly food allergy. The major stimulants of acid secretion are gastrin, histamine, and acetylcholine. Ghrelin and orexin also stimulate acid secretion. The main inhibitor of acid secretion is somatostatin. Nitric oxide and dopamine also inhibit acid secretion. Although Helicobacter pylori is associated with duodenal ulcer disease, most patients infected with the organism produce less than normal amount of acid. The cytoskeletal proteins ezrin and moesin participate in parietal cell acid and chief cell pepsinogen secretion, respectively. SUMMARY: Despite our vast knowledge, the understanding of the regulation of gastric acid secretion in health and disease is far from complete. A better understanding of the pathways and mechanisms regulating acid secretion should lead to improved management of patients with acid-induced disorders as well as those who secrete too little acid.
Mitchell L Schubert
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  25     ISSN:  1531-7056     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-14     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-36     Citation Subset:  IM    
Department of Medicine, Division of Gastroenterology, Virginia Commonwealth University Health System and McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.
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MeSH Terms
Acetylcholine / physiology
Cytoskeletal Proteins / physiology
Gastric Acid / secretion*
Gastric Mucosa / secretion*
Gastrins / physiology
Ghrelin / physiology
Helicobacter Infections / metabolism
Helicobacter pylori
Histamine / physiology
Intracellular Signaling Peptides and Proteins / physiology
Microfilament Proteins / physiology
Neuropeptides / physiology
Parietal Cells, Gastric / secretion*
Pepsinogen A / secretion
Stomach / metabolism*
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Gastrins; 0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Microfilament Proteins; 0/Neuropeptides; 0/ezrin; 0/orexins; 144131-77-1/moesin; 51-45-6/Histamine; 51-84-3/Acetylcholine; 9001-10-9/Pepsinogen A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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