Document Detail

Gastric epithelial damage induced by local ischemia-reperfusion with or without exogenous acid.
MedLine Citation:
PMID:  8141300     Owner:  NLM     Status:  MEDLINE    
We evaluated the damage to the gastric epithelium produced by local ischemia-reperfusion (IR) with or without luminal perfusion with 0.1 N HCl. Local gastric ischemia was induced by clamping the left gastric artery. Use of radioactive microsphere technique revealed a significant reduction in blood flow induced only in the corpus (67% reduction). Because no measurable gross lesion was observed in this model, the blood-to-lumen clearance of 51Cr-labeled EDTA (51Cr-EDTA) served as an index of epithelial damage. In the absence of exogenous acid, the histological damage was minimum and could not be quantified. However, a significant increase in 51Cr-EDTA clearance was observed shortly after reperfusion in a manner that depended on the duration of ischemia. This increase in clearance reached a maximum approximately 10 min after reperfusion and returned rapidly toward control levels within 40-50 min after reperfusion. In the presence of exogenous acid, EDTA clearance increased significantly during ischemia, increased further during reperfusion, and did not recover for at least 60 min after reperfusion. The acid infused after reperfusion (no acid before reperfusion) did not significantly aggravate the mucosal damage that followed reperfusion. However, the acid infused before reperfusion (no acid after reperfusion) showed an effect on EDTA clearance similar to that induced by continuous acid perfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
T Kawai; T Joh; F Iwata; M Itoh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-28     Completed Date:  1994-04-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G263-70     Citation Subset:  IM    
First Department of Internal Medicine, Nagoya City University Medical School, Japan.
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MeSH Terms
Allopurinol / pharmacology
Chromium Radioisotopes
Dimethyl Sulfoxide / pharmacology
Edetic Acid / pharmacokinetics
Gastric Mucosa / blood supply*,  drug effects,  pathology*
Hydrochloric Acid / pharmacology*
Rats, Sprague-Dawley
Reperfusion Injury / pathology*
Superoxide Dismutase / pharmacology
Reg. No./Substance:
0/Chromium Radioisotopes; 315-30-0/Allopurinol; 60-00-4/Edetic Acid; 67-68-5/Dimethyl Sulfoxide; 7647-01-0/Hydrochloric Acid; EC Dismutase

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