| Gastric emptying and small bowel transit in male volunteers after i.m. ketorolac and morphine. | |
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MedLine Citation:
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PMID: 1931399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten male volunteers were studied in a randomized, double-blind crossover trial. Each received ketorolac tromethamine 30 mg and morphine sulphate 10 mg i.m. at an interval of 2 weeks. After a standard radiolabelled meal, gastric emptying half-time (GE) and small intestinal transit time (SIT) were measured using a gamma camera. Small intestinal transit time was measured also from end-tidal breath hydrogen (ETH), and overall gastrointestinal motility by time to first flatus (TFF). Mean GE, SIT and TFF were significantly prolonged by morphine compared with ketorolac (P less than 0.03); ETH was prolonged also, but the difference was not significant. There were no significant correlations between SIT, ETH and TFF. Most subjects reported adverse effects after morphine, but only one after ketorolac. |
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Authors:
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M K Yee; W D Evans; P E Facey; M W Hayward; M Rosen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 67 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1991-12-16 Completed Date: 1991-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 426-31 Citation Subset: IM |
Affiliation:
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Department of Anaesthetics, University Hospital of Wales, Cardiff. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology* Double-Blind Method Gastric Emptying / drug effects* Gastrointestinal Transit / drug effects* Humans Injections, Intramuscular Ketorolac Tromethamine Male Morphine / administration & dosage, pharmacology* Tolmetin / administration & dosage, analogs & derivatives*, pharmacology Tromethamine / administration & dosage, analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 26171-23-3/Tolmetin; 57-27-2/Morphine; 74103-07-4/Ketorolac Tromethamine; 77-86-1/Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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