| Gastric emptying and the organization of antro-duodenal pressures in the critically ill. | |
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MedLine Citation:
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PMID: 18069967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The motor dysfunctions underlying delayed gastric emptying (GE) in critical illness are poorly defined. Our aim was to characterize the relationship between antro-duodenal (AD) motility and GE in critically ill patients. AD pressures were recorded in 15 mechanically ventilated patients and 10 healthy volunteers for 2 h (i) during fasting, (ii) following an intragastric nutrient bolus with concurrent assessment of GE using the (13)C-octanoate breath test and (iii) during duodenal nutrient infusion. Propagated waves were characterized by length and direction of migration. Critical illness was associated with: (i) slower GE (GEC: 3.47 +/- 0.1 vs 2.99 +/- 0.2; P = 0.046), (ii) fewer antegrade (duodenal: 44%vs 83%, AD: 16%vs 83%; P < 0.001) and more retrograde (duodenal: 46%vs 12%, AD: 38%vs 4%; P < 0.001) waves, (iii) shorter wave propagation (duodenal: 4.7 +/- 0.3 vs 6.0 +/- 0.4 cm; AD: 7.7 +/- 0.6 vs 10.9 +/- 0.9 cm; P = 0.004) and (iv) a close correlation between GE with the percentage of propagated phase 3 waves that were antegrade (r = 0.914, P = 0.03) and retrograde (r = -0.95, P = 0.014). In critical illness, the organization of AD pressure waves is abnormal and associated with slow GE. |
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Authors:
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M J Chapman; R J Fraser; L K Bryant; R Vozzo; N Q Nguyen; W Tam; B Zacharakis; G Davidson; R Butler; M Horowitz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-07 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 20 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-04 Completed Date: 2008-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 27-35 Citation Subset: IM |
Affiliation:
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Intensive Care Unit, Royal Adelaide Hospital, Adelaide, SA, Australia. marianne.chapman@health.sa.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Critical Illness* Duodenum / physiopathology* Gastric Emptying* Humans Manometry Peristalsis Pressure Pyloric Antrum / physiopathology* Reference Values Respiration, Artificial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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