| Gastric emptying of ingested fat emulsion in rats: implications for studies of fat-induced satiety. | |
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MedLine Citation:
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PMID: 8780238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence that ingested fat acts in the intestine to produce satiety stems from studies showing that intraintestinal infusion of fat emulsion inhibits eating behavior of rats. In this study, we determined the appropriateness of infusion parameters used in these behavioral studies by measuring gastric emptying rates of both the aqueous and lipid components of Intralipid ingested normally by rats. Stomach contents were collected at different times 0-40 min after rats ingested Intralipid containing [14C]polyethylene glycol (PEG) and phenol red (PR) and were assayed for PEG, PR, and fat. The proportion of ingested fat remaining in the stomach was significantly greater than the proportion of ingested PEG or PR at all time points examined. Despite initial gastric emptying of fat during ingestion, consumption of Intralipid (0.5 or 1.1 kcal/ml) did not suppress subsequent solid food intake. The results indicate that 1) ingested fat emulsion rapidly partitions in the rat stomach into an aqueous phase, which empties rapidly, and a lipid phase, which empties slowly, and 2) normal ingestion of Intralipid is not immediately satiating. These observations raise questions about the physiological significance of the rapid and marked suppression of feeding behavior produced by intraintestinal infusion of Intralipid. |
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Authors:
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M I Friedman; I Ramirez; M G Tordoff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 270 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-10-30 Completed Date: 1996-10-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R688-92 Citation Subset: IM |
Affiliation:
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Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / administration & dosage, metabolism* Feeding Behavior* Gastric Emptying / physiology* Male Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DK-36339/DK/NIDDK NIH HHS; MH-50363/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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