Document Detail

Gastric emptying in infants: response to metoclopramide depends on the underlying condition.
MedLine Citation:
PMID:  3351700     Owner:  NLM     Status:  MEDLINE    
In a double-blind, placebo-controlled, randomized study we measured the effect of 1 mg/kg intravenous metoclopramide on the gastric emptying of a 15 ml/kg 5% glucose meal, using a phenol red dye dilution technique. In a group of nine infants referred for multiple daily episodes of regurgitation, metoclopramide doubled the rate of gastric emptying (p less than 0.02). In six infants with prolonged gastroparesis following abdominal surgery, metoclopramide more than doubled the rate of gastric emptying (p less than 0.05). In contrast, in seven infants with gastroparesis related to prematurity, metoclopramide did not significantly change gastric emptying. No extrapyramidal side effects of metoclopramide occurred during the study.
P E Hyman; C E Abrams; A Dubois
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  7     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-04-22     Completed Date:  1988-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Department of Pediatrics, UCLA Harbor-UCLA Medical Center, Torrance 90502.
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MeSH Terms
Double-Blind Method
Gastric Emptying / drug effects*
Gastroesophageal Reflux / drug therapy*,  etiology
Metoclopramide / administration & dosage,  therapeutic use*
Random Allocation
Grant Support
Reg. No./Substance:

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