Document Detail

Gastric emptying in healthy newborns fed an intact protein formula, a partially and an extensively hydrolysed formula.
MedLine Citation:
PMID:  18280619     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Gastric emptying (GE) is influenced by the type of nutrition. The objective of this study was to compare GE in infants fed an intact protein formula (IPF), a partially hydrolysed formula (PHF), and an extensively hydrolysed formula (EHF). METHODS: This was a double-blind, randomized, cross-over study. Following a fasting period of > or = 3 h, 20 healthy newborns were fed IPF, PHF, and EHF containing 50 microl (13)C-octanoic acid (OA). Breath samples were taken before feeding and every 15 min for 4 h thereafter. (13)C-OA breath test was assessed by isotope-ratio mass spectrometry, and GE half-times (t(1/2)) were determined. RESULTS: Seventeen infants with a mean gestational age of 37 wk (range 28-40 wk) and birth weight of 2698 g (range 720-3690 g) completed the study. At study initiation, the mean age was 31 d (range 6 d-13 wk) and the mean weight was 3466 g (range 2100-5700 g). EHF emptied significantly faster than IPF and PHF (medians 46 vs. 55 and 53 min, respectively, Wilcoxon, P<0.05 for both). There was no significant difference between GE of PHF and IPF (Wilcoxon, P=0.2). CONCLUSIONS: EHF may be better tolerated by infants with GE problems.
Sofie Staelens; Mieke Van den Driessche; Denis Barclay; Anne-Lise Carrié-Faessler; Ferdinand Haschke; Kristin Verbeke; Hilde Vandebroek; Karel Allegaert; Bart Van Overmeire; Mieke Van Damme; Gigi Veereman-Wauters
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-02-15
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  27     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  264-8     Citation Subset:  IM    
Pediatric Gastroenterology and Nutrition, Queen Paola Children's Hospital, ZNA, Lindendreef 1, 2018 Antwerp, Belgium.
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MeSH Terms
Breath Tests / methods*
Carbon Isotopes
Cross-Over Studies
Dietary Proteins / metabolism*
Double-Blind Method
Gastric Emptying / drug effects*,  physiology*
Infant Food
Infant Formula* / administration & dosage,  chemistry,  metabolism
Infant, Newborn
Octanoic Acids
Reg. No./Substance:
0/Carbon Isotopes; 0/Dietary Proteins; 0/Octanoic Acids

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