Document Detail


Gastric emptying in diabetic patients by the (13)C-octanoic acid breath test: role of insulin in gastric motility.
MedLine Citation:
PMID:  17671762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. METHODS: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the (13)C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100 mg of (13)C octanoic acid, and at 15-min intervals over a 300-min period postprandially. RESULTS: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed (13)CO(2) excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. CONCLUSIONS: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the (13)C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.
Authors:
Masahiro Matsumoto; Rie Yoshimura; Hirotada Akiho; Naomi Higuchi; Kunihisa Kobayashi; Noriaki Matsui; Kentaro Taki; Hiroyuki Murao; Haruei Ogino; Kenji Kanayama; Yorinobu Sumida; Takahiro Mizutani; Kuniomi Honda; Shigetaka Yoshinaga; Soichi Itaba; Hiromi Muta; Naohiko Harada; Kazuhiko Nakamura; Ryoichi Takayanagi
Publication Detail:
Type:  Journal Article     Date:  2007-06-29
Journal Detail:
Title:  Journal of gastroenterology     Volume:  42     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  IM    
Affiliation:
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Breath Tests
Carbon Isotopes / diagnostic use*
Diabetes Mellitus, Type 1 / physiopathology*
Diabetes Mellitus, Type 2 / physiopathology*
Female
Gastric Emptying*
Humans
Insulin / physiology*
Male
Middle Aged
Octanoic Acids / diagnostic use*
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Octanoic Acids; 11061-68-0/Insulin; 124-07-2/caprylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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