| Gastric emptying in diabetic patients by the (13)C-octanoic acid breath test: role of insulin in gastric motility. | |
| | |
MedLine Citation:
|
PMID: 17671762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients. METHODS: In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the (13)C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100 mg of (13)C octanoic acid, and at 15-min intervals over a 300-min period postprandially. RESULTS: In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed (13)CO(2) excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups. CONCLUSIONS: IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the (13)C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying. |
| | |
Authors:
|
Masahiro Matsumoto; Rie Yoshimura; Hirotada Akiho; Naomi Higuchi; Kunihisa Kobayashi; Noriaki Matsui; Kentaro Taki; Hiroyuki Murao; Haruei Ogino; Kenji Kanayama; Yorinobu Sumida; Takahiro Mizutani; Kuniomi Honda; Shigetaka Yoshinaga; Soichi Itaba; Hiromi Muta; Naohiko Harada; Kazuhiko Nakamura; Ryoichi Takayanagi |
Publication Detail:
|
Type: Journal Article Date: 2007-06-29 |
Journal Detail:
|
Title: Journal of gastroenterology Volume: 42 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-08-02 Completed Date: 2007-10-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
|
Languages: eng Pagination: 469-74 Citation Subset: IM |
Affiliation:
|
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Breath Tests Carbon Isotopes / diagnostic use* Diabetes Mellitus, Type 1 / physiopathology* Diabetes Mellitus, Type 2 / physiopathology* Female Gastric Emptying* Humans Insulin / physiology* Male Middle Aged Octanoic Acids / diagnostic use* |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Isotopes; 0/Octanoic Acids; 11061-68-0/Insulin; 124-07-2/caprylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of leptin on stress-induced changes of caspases in rat gastric mucosa.
Next Document: The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to un...