| Gastric emptying, glucose metabolism and gut hormones: Evaluation of a common preoperative carbohydrate beverage. | |
| | |
MedLine Citation:
|
PMID: 21255977 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the gastric-emptying rate and gut hormonal response of two carbohydrate-rich beverages. A specifically designed carbohydrate-rich beverage is currently used to support the surgical patient metabolically. Fruit-based beverages may also promote recovery, due to natural antioxidant and carbohydrate content. However, gastric emptying of fluids is influenced by its nutrient composition; hence, safety of preoperative carbohydrate loading should be confirmed. Because gut hormones link carbohydrate metabolism and gastric emptying, hormonal responses were studied. METHODS: In eight volunteers, gastric emptying rates of both 400 mL of a ready-to-use beverage (A: Nutricia preOp; 50.4 g carbohydrates---mainly polysaccharides; 260 mOsm/kg) and 400 mL over-the-counter fruit-based lemonade (B: Roosvicee Original; 48 g carbohydrates---mainly fruit-associated saccharides; 805 mOsm/kg) were determined scintigraphically (using hepatate Tc-99(m)) according to a crossover design. Plasma glucose, insulin, C-peptide, glucagon-like peptide (GLP-1), peptide YY, total glucagon, and ghrelin were studied. RESULTS: Gastric emptying showed no differences in residual volumes. Earlier onset in emptying for beverage A versus B was observed (trend), with significantly higher glucose, insulin, C-peptide, and glucagon responses at 15-90 min. GLP-1 was inversely related to residual volume. CONCLUSION: Fruit-based lemonade is a safe alternative for preoperative purposes. It induces a more limited glucose, insulin, and C-peptide response. Later onset in gastric emptying (B versus A: trend), lower glucagon release, and differences in beverage content and osmolarity may have contributed to those differences. Efficient emptying was reflected by early GLP-1 levels. |
| | |
Authors:
|
Mechteld A R Vermeulen; Milan C Richir; Martijn K Garretsen; Annelies van Schie; Mohammed A Ghatei; Jens J Holst; Annemieke C Heijboer; Bernard M J Uitdehaag; Michaela Diamant; E Marelise W Eekhoff; Paul A M van Leeuwen; Gerdien C Ligthart-Melis |
Related Documents
:
|
17130477 - The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type... 1416807 - Subclinical histopathological changes in the oculomotor nerve in diabetes mellitus. 7875047 - Complaints of neuropathy related to the clinical and neurophysiological assessment of n... 5918577 - Odor discrimination in pigeons. 6396097 - Prediction of hyperkalemia associated with prolonged treatment with captopril by glucos... 7479627 - Medication cost savings associated with weight loss for obese non-insulin-dependent dia... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-20 |
Journal Detail:
|
Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: - ISSN: 1873-1244 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8802712 Medline TA: Nutrition Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Surgery, VU University Medical Center, Amsterdam, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A pilot study of QT interval analysis in overweight and obese youth.
Next Document: Extraoral prostheses using extraoral implants.