Document Detail


Gastric emptying of enteric-coated tablets.
MedLine Citation:
PMID:  6321117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the gastric emptying time of pharmaceutical dosage forms in a clinical setting, a relatively simple dual-radionuclide technique was developed. Placebo tablets of six different combinations of shape and size were labeled with indium-111 DTPA and enteric coated. Six volunteers participated in a single-blind and crossover study. Tablets were given in the morning of a fasting stomach with 6 oz of water containing 99mTc pertechnetate and continuously observed with a gamma camera. A scintigraph was obtained each minute. The results suggested that the size, shape, or volume of the tablet used in this study had no significant effect in the rate of gastric emptying. The tablets emptied erratically and unpredictably, depending upon their time of arrival in the stomach in relation to the occurrence of interdigestive myoelectric contractions. The method described is a relatively simple and accurate technique to allow one to follow the gastric emptying of tablets.
Authors:
H M Park; S M Chernish; B D Rosenek; R L Brunelle; B Hargrove; H N Wellman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  29     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-04-10     Completed Date:  1984-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Gastric Emptying*
Humans
Indium / diagnostic use
Male
Middle Aged
Radioisotopes / diagnostic use
Random Allocation
Sodium Pertechnetate Tc 99m
Stomach / radionuclide imaging
Tablets, Enteric-Coated*
Technetium / diagnostic use
Time Factors
Chemical
Reg. No./Substance:
0/Radioisotopes; 0/Tablets, Enteric-Coated; 23288-60-0/Sodium Pertechnetate Tc 99m; 7440-26-8/Technetium; 7440-74-6/Indium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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