| Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure. | |
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MedLine Citation:
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PMID: 16110840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides. |
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Authors:
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Jinhong Xing; Joshua Felsher; Frederick Brody; Edy Soffer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 50 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1481-7 Citation Subset: AIM; IM |
Affiliation:
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Cleveland Clinic Foundation, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Bodies / physiopathology Dogs Efferent Pathways / physiopathology Electric Stimulation* Esophageal Sphincter, Lower / physiopathology* Fasting / physiology Female Manometry Neuropeptides / blood Postprandial Period / physiology Pressure Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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