Document Detail


Gastric electrical stimulation reduces visceral sensitivity to gastric distention in healthy canines.
MedLine Citation:
PMID:  21126929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the effects and mechanisms of gastric electrical stimulation (GES) on proximal stomach distention-induced visceral sensitivity. Isobaric gastric distention was performed using a barostat system in 8 normal and 6 vagotomized dogs and animal behaviors were noted and graded. The normal dogs were studied in 4 sessions: control (no GES), short pulse GES, long pulse GES, and dual-pulse GES, and the vagotomized dogs were studied in three sessions: control (no GES), long pulse GES and guanethidine. It was found that: 1) proximal stomach distention-induced behavioral changes were mediated by vagal and sympathetic pathways. The total behavior score (TBS) was 40.6 ± 7.4 in the controls, 15.3 ± 8.9 in vagotomized dogs (P=0.006 vs. control) and 8.8 ± 0.9 in the vagotomized dogs with guanethidine (P=0.04 vs. vagotomy). The behavioral changes were mediated via the vagal pathway at distention pressures below 20 mmHg, but mediated via both the vagal and sympathetic pathways at distention pressures equal to and above 20 mmHg. 2) GES with long pulses or dual pulses but not short pulses reduced the distention-induced behavioral score (P=0.003, P=0.006 and P=0.7, respectively) and the effects of GES of long pulses might be mediated via the vagal and sympathetic pathways. In conclusion, gastric distention-induced visceral sensitivity is mediated via the vagal pathway at low distention pressures but via both vagal and sympathetic pathways at high distention pressures. GES with long but not short pulses reduces distention-induced visceral sensitivity.
Authors:
Ji-Hong Chen; Geng-Qing Song; Jieyun Yin; Yan Sun; Jiande D Z Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-12-03
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  160     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-05-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electric Stimulation
Female
Pain Threshold / physiology*
Stomach / innervation*,  physiology*
Sympathetic Nervous System / physiology*
Vagus Nerve / physiology
Grant Support
ID/Acronym/Agency:
1R43CA121489/CA/NCI NIH HHS; R44 DK055437/DK/NIDDK NIH HHS; R44 DK055437-03/DK/NIDDK NIH HHS
Comments/Corrections

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