Document Detail


Gastric electrical stimulation reduces gastric tone energy dependently.
MedLine Citation:
PMID:  15764145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Impaired gastric accommodation is one of the major pathophysiological factors in functional dyspepsia (FD). Gastrointestinal electric stimulation (GES) as a potential therapy for treating patients with motility disorders has been applied in animal models and clinical practice. However, the response of proximal gastric tone to different GES has not been fully understood. Therefore, the aims of this study were to investigate the effects of GES with different parameters on gastric tone and to estimate the relationship between gastric volume, stimulation energy, and symptoms. MATERIAL AND METHODS: Seven dogs equipped with a gastric cannula and two pairs of serosal electrodes in the greater curvature were studied with different GES via a pair of electrodes located 10-14 cm above the pylorus. The gastric volume under constant pressure was measured using a barostat device. RESULTS: The results showed that 1) GES increased the gastric volume in a dose-dependent manner with the increase of stimulation frequency or pulse amplitude. 2) The increase in gastric volume with GES was significantly correlated to stimulation energy. 3) Mild symptoms were noted with stimulation and the score of the induced symptoms was linearly and significantly correlated with gastric volume. CONCLUSIONS: GES decreases the proximal gastric tone in an energy-dependent manner. These data suggest that GES could be used to treat patients with impaired gastric accommodation.
Authors:
Y Sun; J D Z Chen
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  40     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-14     Completed Date:  2005-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  154-9     Citation Subset:  IM    
Affiliation:
Transneuronix Inc., Oklahoma City, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Dyspepsia / physiopathology,  therapy
Electric Stimulation Therapy*
Female
Gastrointestinal Motility / physiology*
Muscle Tonus / physiology
Stomach / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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