| Gastric electrical stimulation on gastric motility in dogs. | |
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MedLine Citation:
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PMID: 21992252 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: The aim of this study was to systematically evaluate and compare the effects of synchronized dual-pulse gastric electrical stimulation (SDPS) and conventional gastric electrical stimulation (CGES) on antral contractions, gastric tone, and autonomic functions. Methods: Seven female hound dogs implanted with four pairs of electrodes on gastric serosa were studied in two separate experiments. The first experiment was designed to investigate the effects of SDPS/CGES on gastric tone and heart rate variations. The second experiment was performed to study the effects of SDPS/CGES on antral contractions. Results: 1) SDPS induced gastric antral contractions in the fasting state, whereas CGES at the intrinsic or a tachygastrial frequency had no effects on fasting antral contractions. 2) SDPS enhanced postprandial antral contractions impaired by glucagon; however, CGES at a tachygastrial frequency inhibited postprandial antral contractions. In addition, CGES at the intrinsic frequency of the stomach had no effects on postprandial antral contractions. 3) SDPS or CGES at the intrinsic frequency of the stomach had no effects on gastric tone, but CGES at a tachygastrial frequency reduced gastric tone. 4) SDPS excited vagal activity, but CGES at a tachygastrial frequency inhibited vagal activity. Conclusions: SDPS improves antral contractions but does not affect gastric tone and thus may have potential for treating gastric motility disorders. CGES at a tachygastrial frequency inhibits gastric tone and contractions and may be applicable for treating obesity. The excitatory or inhibitory effects of SDPS/CGES on gastric motility may be mediated via vagal pathway. |
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Authors:
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Geng-Qing Song; Jiande D Z Chen |
Publication Detail:
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Type: Journal Article Date: 2011-03-01 |
Journal Detail:
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Title: Neuromodulation : journal of the International Neuromodulation Society Volume: 14 ISSN: 1525-1403 ISO Abbreviation: Neuromodulation Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804159 Medline TA: Neuromodulation Country: United States |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: IM |
Copyright Information:
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© 2011 International Neuromodulation Society. |
Affiliation:
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Veterans Research Foundation, VA Medical Center, Oklahoma City, OK, USA; and Division of Gastroenterology, University of Texas Medical Branch at Galveston, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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