| Gastric electrical stimulation is an effective and safe treatment for medically refractory gastroparesis. | |
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MedLine Citation:
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PMID: 18847640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gastroparesis is characterized by delayed gastric emptying in the absence of obstruction. Common symptoms include nausea, vomiting, and abdominal pain. Severe gastroparesis can result in recurrent hospitalizations, malnutrition, and even death. Gastric electrical stimulation (GES) is a low morbidity treatment that may be effective in patients who are refractory to medical therapy. METHODS: For a period of more than 35 months, 19 GES systems were implanted laparoscopically for refractory gastroparesis of diabetic (DG, n = 10), idiopathic (IG, n = 6), or postsurgical (PSG, n = 3) etiology. Total gastroparesis symptom scores (TSS) and weekly vomiting frequency were assessed. Gastric emptying studies were attained preoperatively and after 6 months. RESULTS: Mean follow-up was 38 weeks. There were no major complications. Within 6 weeks, frequency of vomiting decreased in 75% of DG (6/8) and 100% of IG (4/4) patients. No PSG patient complained of vomiting preoperatively. Mean TSS scores improved significantly at all intervals out to 1 year. Gastric emptying studies normalized in 80% of DG patients but in only 1 of the 6 patients with gastroparesis due to other causes. CONCLUSION: GES therapy can lead to improvement in symptoms of gastroparesis and frequency of vomiting within 6 weeks. This therapy is a low morbidity treatment option that may help patients whose symptoms fail to improve with medical therapy. |
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Authors:
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Daniel McKenna; Gretchen Beverstein; Mark Reichelderfer; Eric Gaumnitz; Jon Gould |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 144 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 566-72; discussion 572-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Electric Stimulation Therapy / methods* Electrodes, Implanted Female Follow-Up Studies Gastric Emptying / physiology Gastroparesis / diagnosis*, therapy* Gastroscopy / methods Humans Male Patient Satisfaction Probability Quality of Life* Risk Assessment Severity of Illness Index Statistics, Nonparametric Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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