Document Detail

Gastric electrical stimulation does not significantly affect canine gastric acid secretion and 24-hour gastric pH.
MedLine Citation:
PMID:  14992434     Owner:  NLM     Status:  MEDLINE    
Gastric electrical stimulation (GES) was shown to improve symptoms in patients with gastroparesis. However, the underlying mechanisms remain unclear. This study assessed the influence of various patterns of GES on fasting and postprandial gastric acid secretion and 24-hr gastric pH. Eight healthy dogs were studied and we found that in the fasting state, low-frequency, long-pulse (6/12-cpm, 375-msec, 4-mA) GES at the proximal stomach significantly inhibited the secretion of gastric juice (P < 0.05). No such effect was observed during GES (6/12 cpm) at the distal stomach. In the postprandial period, low-frequency, long-pulse GES at both proximal and distal sites and at both frequencies did not significantly affect gastric acid secretion. High-frequency, short-pulse GES, investigated for obesity (21 Hz, 8 mA, and 250 microsec, with 2 secs on, 3 sec off), at the proximal and distal stomach did not significantly affect the 24-hr gastric pH profile. In conclusion, GES with various stimulation parameters, and at various sites, has little effect on gastric acid secretion. The clinical effects induced by GES at these parameters may not be related to their effect on gastric acid homeostasis.
Jin-Hong Xing; Michael Rosen; Frederick Brody; Edy E Soffer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  49     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-02     Completed Date:  2004-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  AIM; IM    
Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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MeSH Terms
Circadian Rhythm
Electric Stimulation
Gastric Acid / physiology*
Hydrogen-Ion Concentration
Postprandial Period
Reference Values
Stomach / physiology*

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