| Gastric electrical activity and gastrointestinal hormones in dyspeptic patients. | |
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MedLine Citation:
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PMID: 11173896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To explore the patterns of gastric electrical activity, gastric emptying and gastrointestinal hormones in dyspeptic patients and relate them to Helicobacter pylori status. METHODS: Twenty-two patients with functional dyspepsia and 29 healthy volunteers underwent cutaneous electrogastrography and dynamic ultrasound before and after a test meal. All dyspeptic patients underwent endoscopy and biopsy; all subjects were examined for the presence of antibodies to H. pylori, and the plasma levels of gastrin, neurotensin, cholecystokinin, and pancreatic polypeptide were measured. RESULTS: The area under the curve (AUC) of the normal slow wave percentage was lower in dyspeptic patients than controls (Kruskal-Wallis p = 0.016; Dunn's test: H. pylori-positive patients: 21,235.5 [19,101.0-22,688.8] vs. H. pylori-negative controls: 22,532.0 [20,133.0-23,755.0], p < 0.05). The AUC of the tachygastria percentage was higher in dyspeptic patients than controls (p = 0.0001; H. pylori-positive patients: 2,173.5 [325.8-3,055.3] vs. H. pylori-negative controls: 682.0 [118.5-1,902.4], p < 0.05; H. pylori-negative patients: 1,843.0 [1,107.0-4,277.0] vs. H. pylori-negative controls: 682.0 [118.5-1,902.4], p < 0.05). The AUC of gastrin was higher in H. pylori-positive than H. pylori-negative subjects (p = 0.0002; H. pylori-positive patients: 16,146.5 [11,368.8-33,141.7] vs. H. pylori-negative controls: 11,250.0 [5,674.0-17,448.0], p < 0.05; H. pylori-positive controls: 20,250.0 [12,070.0-64,430.0] vs. H. pylori-negative controls: 11,250.0 [5,674.0-17,448.0], p < 0.05). In the total group of dyspeptic patients and in the H. pylori-positive patients, a negative correlation was found between the AUC of neurotensin and the total score for postprandial fullness (dyspeptic patients r = -0.51, p = 0.01; H. pylori-positive patients r = -0.66, p = 0.02). CONCLUSIONS: In dyspeptic patients, alterations in gastric electrical activity were not related to H. pylori infection. Nevertheless, H. pylori infection induces higher gastrin levels in both patients and asymptomatic subjects. |
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Authors:
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G Riezzo; M Chiloiro; F Russo; C Clemente; G Di Matteo; V Guerra; A Di Leo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestion Volume: 63 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 2001 |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 20-9 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Laboratory of Experimental Pathophysiology, Scientific Institute of Gastroenterology, Via F. Valente, 4, I-70013 Castellana Grotte, Bari, Italy. giriezzo@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dyspepsia / microbiology, physiopathology* Electrophysiology Female Gastric Emptying Gastrointestinal Hormones / metabolism* Helicobacter Infections / complications* Helicobacter pylori / isolation & purification, pathogenicity Humans Male Middle Aged Postprandial Period |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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