Document Detail

Gastric electrical activity and gastric emptying in preterm newborns fed standard and hydrolysate formulas.
MedLine Citation:
PMID:  11593124     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Because infant formulas containing hydrolyzed cow milk protein are used to reduce feeding intolerance and to improve gastric emptying, the effect on gastrointestinal motility of a hydrolysate formula was compared with that of a standard preterm formula. METHODS: Thirty-six preterm newborns with a gestational age of 32.2 +/- 2.3 weeks were assigned randomly to standard formula or hydrolyzed formula. Cutaneous electrogastrography and ultrasound examination of gastric emptying were performed simultaneously to evaluate gastrointestinal motility before and after the test meal. All recording sessions were performed 1 week after infants had reached full enteral feeding. RESULTS: No significant difference in gastrointestinal symptoms was noted in the newborns fed the different formulas. In particular, regurgitation and vomiting were observed in 78% versus 64% of preterm newborns after standard and hydrolyzed formula, respectively (Fisher exact test, not significant). No differences were found in terms of gastric electrical activity and gastric emptying time between the two groups. CONCLUSIONS: It seems unnecessary to use hydrolysate formulas to improve motility in preterm infants.
G Riezzo; F Indrio; O Montagna; C Tripaldi; N Laforgia; M Chiloiro; A Mautone
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  33     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-10     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Laboratory of Experimental Pathophysiology, IRCCS S de Bellis, Castellana Grotte, Bari, Italy.
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MeSH Terms
Gastric Emptying / physiology
Gastrointestinal Motility / physiology*
Gestational Age
Infant Food*
Infant, Newborn
Infant, Premature / physiology*
Milk Proteins / administration & dosage,  metabolism
Stomach / physiology*,  ultrasonography
Time Factors
Reg. No./Substance:
0/Milk Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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