| Gastric distention: a mechanism for postprandial gastroesophageal reflux. | |
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MedLine Citation:
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PMID: 4029557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The occurrence of gastroesophageal reflux after meals may be related to an increase in the rate of transient lower esophageal sphincter (LES) relaxations, the mechanisms of which are not understood. We investigated the effects of gastric distention on LES pressure in 16 normal subjects and 17 patients with gastroesophageal reflux disease. Intraluminal pressure was measured in the gastric fundus, LES, and esophageal body with a manometric catheter incorporating a sleeve device. Gastric distention was performed by injecting 0, 250, 500, or 750 ml of air in randomized order into a balloon and maintaining each stimulus for 15 min. Gastric distention did not significantly alter resting LES pressure in either group. During the basal period the rate of transient LES relaxation in the reflux patients (1.1 +/- 0.4 per 15 min) was greater than that in the normal subjects (0.6 +/- 0.1 per 15 min). Gastric distention resulted in a significant threefold to fourfold increase in the rate of transient LES relaxations in both groups. The reflux patients had a significantly greater proportion of complete relaxations (87%) than did the normal subjects (73%). We conclude that gastric distention, by significantly increasing the rate of transient LES relaxations in both normal subjects and patients with gastroesophageal reflux disease, may contribute to the postprandial increase in gastroesophageal reflux. |
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Authors:
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R H Holloway; M Hongo; K Berger; R W McCallum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 89 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-08 Completed Date: 1985-10-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 779-84 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Eating Female Gastroesophageal Reflux / physiopathology* Humans Male Manometry / methods Middle Aged Muscle Relaxation Pressure Stomach / physiopathology* |
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