| Gastric digestion modifies absorption of butterfat into lymph chylomicrons in rats. | |
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MedLine Citation:
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PMID: 9868188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to characterize the time course of mesenteric lymph output, lipid composition and size of lymph chylomicrons in rats given gastric infusion of lipid emulsions containing defined fractions of butterfat, palm oil or corn oil. The concentrations of cholesterol, triacylglycerol (TAG) and phospholipid in lymph obtained before lipid infusion were 1.4-2.5-fold greater in rats chronically fed palm oil or solid butterfat compared with corn oil or liquid butterfat (P = 0.02). Total lymph chylomicron TAG output (mg/24 h) stimulated by gastric lipid infusion was 21% greater with corn oil compared with all saturated fats (P = 0.02). Total lymph chylomicron cholesterol output was 1.3-8.6-fold greater than the amount infused in all groups (P = 0.03) and was independent of the amount of cholesterol infused. The size distribution as well as the mean, median and modal diameters of lymph chylomicrons isolated during peak lymphatic TAG output were not significantly different among treatments. The fatty acid and TAG profiles of lymph chylomicrons obtained from rats infused with corn or palm oil did not differ significantly from that of the emulsion infused. In contrast, gastric lipolysis of butterfat significantly modified the lipid composition of lymph chylomicrons. We observed progressive disappearance of short- and medium-chain fatty acids in gastric contents and an absence of detectable short-chain fatty acids with concurrent proportionate increases in long-chain fatty acids and large TAG molecules in lymph chylomicrons compared with butterfat emulsions. These studies demonstrate that gastric digestion is an important modifier of lipid absorption. |
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Authors:
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H C Lai; D M Ney |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 128 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-27 Completed Date: 1999-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2403-10 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Chylomicrons / isolation & purification, metabolism* Corn Oil / administration & dosage, metabolism Dietary Fats / administration & dosage, metabolism*, pharmacology Digestion / drug effects* Emulsions Infusions, Parenteral Intestinal Absorption Lipid Metabolism* Lipids / administration & dosage, pharmacology Lymph / metabolism* Male Mesentery / metabolism Plant Oils / administration & dosage, metabolism Rats Rats, Sprague-Dawley Stomach / drug effects, metabolism Time Factors Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats; 0/Emulsions; 0/Lipids; 0/Plant Oils; 0/Triglycerides; 8001-30-7/Corn Oil; 8002-75-3/palm oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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