| Gastric cytoprotection in man by prostaglandin E2. | |
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MedLine Citation:
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PMID: 7034158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In healthy volunteers, the effects of topical prostaglandins E2 (PGE2), 1 mg, on transmucosal potential difference (PD), mucus secretion, and epithelial cell turnover were investigated. PGE2 increased gastric PD by 10 mV on an average and stimulated mucus secretion of the stomach by 50%. In contrast, epithelial cell turnover remained unchanged. Gastric output of H+ decreased, whereas the outputs of volume, Na+, and Cl- rose in response to PGE2, which effects would be compatible with increased secretion of bicarbonate. Topical administration of ethanol 40% (vol/vol) reduced PD by 25 mV (delta PDE) and enhanced epithelial cell shedding by 350% with concomitant discharge of mucus from stomach epithelium. Pretreatment of the stomach with 1 mg PGE2 prevented the ethanol-dependent epithelial cell exfoliation, indicating gastric mucosal cytoprotection. Delta PDE and discharge of mucus were not significantly altered by PGE2. We conclude that gastric cytoprotection by PGE2 in man might be mediated by stimulation of mucus and/or bicarbonate production. |
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Authors:
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H Ruppin; B Person; A Robert; W Domschke |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 16 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1981 |
Date Detail:
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Created Date: 1982-03-13 Completed Date: 1982-03-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 647-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Ulcer Agents Clinical Trials as Topic Dinoprostone Female Gastric Acid / secretion Gastric Mucosa / cytology*, secretion Humans Male Membrane Potentials / drug effects Mucus / secretion Prostaglandins E / therapeutic use* Random Allocation Stimulation, Chemical Stomach Ulcer / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Prostaglandins E; 363-24-6/Dinoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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