Document Detail

Gastric contractions produce phasic changes in perfusion pressure.
MedLine Citation:
PMID:  1677534     Owner:  NLM     Status:  MEDLINE    
This study examined the relationship between motility and perfusion pressure of an ex vivo segment of the canine stomach perfused at constant flow. Changes in luminal pressure were used to quantitate contractile force. Under control conditions, spontaneous contractions increased luminal pressure by 18.8 +/- 1.1 mmHg and gastric perfusion pressure by 14.2 +/- 0.8 mmHg. Changes in luminal and perfusion pressures during contractions were highly correlated (r2 = 0.963, P less than 0.0001, 109 observations in 5 dogs). In separate studies, we assessed the effects of atropine, neostigmine (an acetylcholinesterase inhibitor), and bethanechol (a muscarinic cholinergic agonist). Atropine attenuated the peristaltic-induced changes in perfusion pressure in a concentration-dependent manner (10(-9) to 10(-6)M) with nearly total inhibition at the highest dose. Neostigmine (10(-9) to 10(-6) M) and bethanechol (10(-8) to 10(-5) M) stimulated contractions, resulting in dose-related increases in luminal and perfusion pressures. Our results demonstrate that cholinergic-dependent contractions produce marked, phasic changes in gastric perfusion pressure.
J G Wood; L Y Cheung
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  261     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-27     Completed Date:  1991-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G158-65     Citation Subset:  IM    
Department of Surgery, University of Kansas Medical Center, Kansas City 66103.
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MeSH Terms
Atropine / diagnostic use
Bethanechol Compounds / diagnostic use
Blood Pressure
Cholinergic Antagonists
Cholinesterase Inhibitors / diagnostic use
Gastrointestinal Motility*
Neostigmine / diagnostic use
Regional Blood Flow
Stomach / blood supply*,  physiology*
Grant Support
Reg. No./Substance:
0/Bethanechol Compounds; 0/Cholinergic Antagonists; 0/Cholinesterase Inhibitors; 51-55-8/Atropine; 59-99-4/Neostigmine; 674-38-4/Bethanechol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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