| Gastric contractions produce phasic changes in perfusion pressure. | |
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MedLine Citation:
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PMID: 1677534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the relationship between motility and perfusion pressure of an ex vivo segment of the canine stomach perfused at constant flow. Changes in luminal pressure were used to quantitate contractile force. Under control conditions, spontaneous contractions increased luminal pressure by 18.8 +/- 1.1 mmHg and gastric perfusion pressure by 14.2 +/- 0.8 mmHg. Changes in luminal and perfusion pressures during contractions were highly correlated (r2 = 0.963, P less than 0.0001, 109 observations in 5 dogs). In separate studies, we assessed the effects of atropine, neostigmine (an acetylcholinesterase inhibitor), and bethanechol (a muscarinic cholinergic agonist). Atropine attenuated the peristaltic-induced changes in perfusion pressure in a concentration-dependent manner (10(-9) to 10(-6)M) with nearly total inhibition at the highest dose. Neostigmine (10(-9) to 10(-6) M) and bethanechol (10(-8) to 10(-5) M) stimulated contractions, resulting in dose-related increases in luminal and perfusion pressures. Our results demonstrate that cholinergic-dependent contractions produce marked, phasic changes in gastric perfusion pressure. |
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Authors:
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J G Wood; L Y Cheung |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 261 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-08-27 Completed Date: 1991-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G158-65 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Kansas Medical Center, Kansas City 66103. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / diagnostic use Bethanechol Bethanechol Compounds / diagnostic use Blood Pressure Cholinergic Antagonists Cholinesterase Inhibitors / diagnostic use Dogs Gastrointestinal Motility* Male Neostigmine / diagnostic use Perfusion Regional Blood Flow Stomach / blood supply*, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK-25998/DK/NIDDK NIH HHS; DK-35191/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bethanechol Compounds; 0/Cholinergic Antagonists; 0/Cholinesterase Inhibitors; 51-55-8/Atropine; 59-99-4/Neostigmine; 674-38-4/Bethanechol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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