| Gastric compliance in bulimia nervosa. | |
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MedLine Citation:
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PMID: 16376390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bulimia nervosa (BN) is a psychiatric illness characterized by eating binges followed by inappropriate behavioral attempts to compensate for the binges, usually vomiting or laxative abuse. Patients with BN have disturbances in the development of satiety during a meal as well as disturbances in functions of the upper gastrointestinal tract such as slowed gastric emptying, impaired gastric accommodation reflex and blunted cholecystokinin release. The present study examined gastric compliance and sensory responses to gastric distention in women with BN and controls. Sixteen women with BN and 13 healthy control subjects swallowed an inflatable bag that was placed in the proximal stomach. The bag was inflated to produce increasing steps of pressure against the stomach wall, before and after consumption of a 200 ml (200 Kcal) liquid meal. Pressure and volume were recorded for 2-min periods, beginning at 0 mm Hg pressure and increasing in steps of 2 mm Hg until subjects reported discomfort, gastric volume reached 600 ml, or pressure reached 20 mm Hg. At each pressure step subjects made sensory ratings. Gastric compliance was calculated as the slope of the best-fit straight line of each subject's gastric volume vs. gastric pressure. There was a significant postmeal increase in gastric compliance in both groups of subjects but there was no difference in compliance between patients with BN and controls. Patients with BN appeared to have diminished sensitivity to gastric distention. In conclusion, although other studies have described gastrointestinal abnormalities associated with BN, the current study found gastric compliance of patients with BN to be normal. |
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Authors:
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E J Zimmerli; B Timothy Walsh; J L Guss; M J Devlin; H R Kissileff |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-12-22 |
Journal Detail:
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Title: Physiology & behavior Volume: 87 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-06 Completed Date: 2006-04-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Columbia University, Columbia University College of Physicians and Surgeons, New York NY 10032 USA. ez26@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Body Weight / physiology Bulimia / physiopathology*, psychology Compliance Data Interpretation, Statistical Female Gastric Emptying / physiology Humans Psychiatric Status Rating Scales Questionnaires Stomach / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH24406/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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