| Gastric carcinoma with lymphoid stroma: incidence of EBV and Helicobacter pylori infection. | |
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MedLine Citation:
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PMID: 12777999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphoepithelioma-like carcinoma (LELC) of the stomach is reported to be associated with Epstein-Barr virus (EBV) and to have a better prognosis than typical adenocarcinoma. However, the incidence of EBV and its association with Helicobacter pylori is controversial. In our series, 9 of 370 (2.4%) cases of gastric adenocarcinoma were LELC. Formalin-fixed, paraffin-embedded LELC tissue was immunostained with monoclonal antibodies against CD3, CD20, and Ki-67. Warthin-Starry stain for H. pylori and in situ hybridization for EBV were performed. As a control, 21 cases of adenocarcinoma with prominent lymphoid stroma were compared with LELC. The most common location of LELC was the body of the stomach (five cases), followed by the cardia (two cases), whereas the antrum was the most common site for the control group. There were no significant differences in age, sex, or lymph node metastasis between the LELC and control groups. The mean Ki-67 index was similar (38.2% in LELC versus 35.3% in control). H. pylori was found in 2 LELC cases (22%) and 6 controls (28.5%). EBV was positive in 7 LELC cases (77.8%) and 4 controls (19.0%). All patients with LELC are alive and well, whereas three patients have died of their disease in the control group. Although EBV appeared to be a contributing factor, H. pylori had a minor role in LELC. There were no clinicopathologic differences between LELC and the control group, except for the location of the tumor in the body of the stomach and the tendency toward a better prognosis in LELC. |
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Authors:
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Hye Jae Cho; Jung Yeon Kim; Jinye Yoo; Sang Sook Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry Volume: 11 ISSN: 1541-2016 ISO Abbreviation: Appl. Immunohistochem. Mol. Morphol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-02 Completed Date: 2004-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888796 Medline TA: Appl Immunohistochem Mol Morphol Country: United States |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea. hcho@sanggyepaik.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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pathology,
virology Case-Control Studies Epstein-Barr Virus Infections / complications*, epidemiology Female Helicobacter Infections / complications*, epidemiology Helicobacter pylori Humans Immunohistochemistry Incidence Ki-67 Antigen / analysis Lymphoid Tissue / pathology, virology Male Middle Aged Prognosis Stomach Neoplasms / epidemiology, pathology*, virology* Stromal Cells |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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