| Gastric bypass reduces biochemical cardiac risk factors. | |
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MedLine Citation:
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PMID: 17196442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coronary artery disease (CAD) is the leading cause of death in the United States, with obesity as a leading preventable risk factor for CAD. Certain biochemical markers have demonstrated strong prediction for cardiovascular events. We hypothesized that in addition to weight reduction, gastric bypass will also induce a salutary effect on the biochemical cardiac risk factors. METHODS: At a single academic institution, from 2003 to 2004, we measured the biochemical cardiac risk factors in gastric bypass patients preoperatively and at 3, 6, and 12 months postoperatively. These risk factors included total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol/HDL cholesterol ratio, triglyceride/HDL cholesterol ratio, triglycerides, lipoprotein A, high-sensitivity C-reactive protein, and homocysteine. The data were analyzed using the Wilcoxon signed rank test. RESULTS: The mean age of the 356 patients was 43 years; 84% were women; the mean body mass index was 47 kg/m(2); 33% were diabetic; 50% were hypertensive; 23% were taking lipid-lowering medications; and 2% had known CAD. Significant improvement occurred in the biochemical cardiac factors from preoperatively to 12 months. The beneficial changes were as follows: total cholesterol, 192 mg/dL preoperatively to 166 mg/dL at 12 months; HDL cholesterol, 46 mg/dL preoperatively to 54 mg/dL at 12 months; low-density lipoprotein, 125 mg/dL preoperatively to 88 mg/dL at 12 months; total cholesterol/HDL cholesterol ratio, 4 preoperatively to 3 at 12 months; triglyceride/HDL cholesterol ratio, 3 preoperatively to 2 at 12 months; triglycerides, 133 mg/dL preoperatively to 92 mg/dL at 12 months; lipoprotein A, 14 mg/dL preoperatively to 13 mg/dL at 12 months; high-sensitivity C-reactive protein, 8 mg/L preoperatively to 1 mg/L; and homocysteine, 10 mumol/L preoperatively to 8 mumol/L at 12 months. CONCLUSIONS: The results of our study have shown that gastric bypass significantly improves all biochemical markers of CAD risk, particularly C-reactive protein, which had an 80% reduction. As a result, gastric bypass decreases the cardiac risk by both weight loss and advantageous alterations of biochemical cardiac risk factors. |
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Authors:
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D Brandon Williams; Judith C Hagedorn; Elise H Lawson; Joseph A Galanko; Bassem Y Safadi; Myriam J Curet; John M Morton |
Publication Detail:
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Type: Journal Article Date: 2006-12-27 |
Journal Detail:
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Title: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Volume: 3 ISSN: 1550-7289 ISO Abbreviation: - Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-01-23 Completed Date: 2007-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101233161 Medline TA: Surg Obes Relat Dis Country: United States |
Other Details:
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Languages: eng Pagination: 8-13 Citation Subset: IM |
Affiliation:
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Department of Surgery, Stanford School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305-5655, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood C-Reactive Protein / analysis Cardiovascular Diseases / blood*, etiology Cholesterol / blood Female Gastric Bypass* Hemoglobin A, Glycosylated Hemoglobins / analysis Homocysteine / blood Humans Lipoprotein(a) / blood Male Obesity / blood*, complications, surgery* Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobin A, Glycosylated; 0/Hemoglobins; 0/Lipoprotein(a); 0/Triglycerides; 0/hemoglobin A1c protein, human; 454-28-4/Homocysteine; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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