Document Detail


Gastric bypass and banding equally improve insulin sensitivity and β cell function.
MedLine Citation:
PMID:  23187122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bariatric surgery in obese patients is a highly effective method of preventing or resolving type 2 diabetes mellitus (T2DM); however, the remission rate is not the same among different surgical procedures. We compared the effects of 20% weight loss induced by laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin sensitivity, and β cell function in nondiabetic obese adults. The metabolic response to meal ingestion was markedly different after RYGB than after LAGB surgery, manifested by rapid delivery of ingested glucose into the systemic circulation, by an increase in the dynamic insulin secretion rate, and by large, early postprandial increases in plasma glucose, insulin, and glucagon-like peptide-1 concentrations in the RYGB group. However, the improvement in oral glucose tolerance, insulin sensitivity, and overall β cell function after weight loss were not different between surgical groups. Additionally, both surgical procedures resulted in a similar decrease in adipose tissue markers of inflammation. We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults.
Authors:
David Bradley; Caterina Conte; Bettina Mittendorfer; J Christopher Eagon; J Esteban Varela; Elisa Fabbrini; Amalia Gastaldelli; Kari T Chambers; Xiong Su; Adewole Okunade; Bruce W Patterson; Samuel Klein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-26
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4667-74     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD11b / metabolism
Area Under Curve
Body Composition
Ceramides / metabolism
Cytokines / metabolism
Diglycerides / metabolism
Female
Gastric Bypass*
Gastroplasty*
Humans
Inflammation Mediators / metabolism
Insulin / secretion
Insulin Resistance*
Insulin-Secreting Cells / physiology*,  secretion
Intra-Abdominal Fat / metabolism,  pathology
Male
Membrane Glycoproteins / metabolism
Middle Aged
Mucins / metabolism
Muscle, Skeletal / metabolism
Obesity / metabolism,  pathology,  surgery*
Organ Size
Postprandial Period
Receptors, G-Protein-Coupled / metabolism
Weight Loss
Grant Support
ID/Acronym/Agency:
DK 37948/DK/NIDDK NIH HHS; DK 56341/DK/NIDDK NIH HHS; P30 DK020579/DK/NIDDK NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P41 RR000954/RR/NCRR NIH HHS; R01 DK037948/DK/NIDDK NIH HHS; RR-00954/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD11b; 0/Ceramides; 0/Cytokines; 0/Diglycerides; 0/EMR1 protein, human; 0/ITGAM protein, human; 0/Inflammation Mediators; 0/Insulin; 0/Membrane Glycoproteins; 0/Mucins; 0/Receptors, G-Protein-Coupled
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An unusual cause of massive pleural effusion.
Next Document:  A calcium channel mutant mouse model of hypokalemic periodic paralysis.