Document Detail


Gastric axial forces in experimentally delayed and accelerated gastric emptying.
MedLine Citation:
PMID:  8498519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to assess the relationship between altered axial forces and gastric emptying of solids by experimentally inhibiting or stimulating gastric axial forces by intraduodenal lipid or intravenous erythromycin, respectively. In 15 healthy volunteers, we simultaneously measured gastric emptying of solids by scintigraphy, gastroduodenal motility by manometry, and forces along the longitudinal axis of the distal stomach by an axial force transducer. When 25% of the radiolabel had emptied from the stomach, subjects (n = 5 in each group) received normal saline (controls), intraduodenal lipid, or intravenous erythromycin. The test period consisted of the infusion period (10 min) and the subsequent 30 min. Lipid significantly reduced and erythromycin increased axial forces compared with control (lipid: median 0.6 N [0-1.4 interquartile range (IQR)]; erythromycin: median 18.2 N (16.5-20.5 IQR); control: median 4.7 N (3.9-5.2 IQR); P < 0.01). Similarly, antral phasic pressure activities were different relative to control. Gastric axial forces correlated significantly with gastric emptying (Spearman rank correlation = 0.86; P < 0.01). These data are consistent with the hypothesis that axial forces affect gastric emptying of solids and suggest that measurement of axial forces provides an assessment of overall gastric propulsion during the emptying of solids.
Authors:
C M Prather; M Camilleri; G M Thomforde; L A Forstrom; A R Zinsmeister
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-22     Completed Date:  1993-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G928-34     Citation Subset:  IM    
Affiliation:
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Adult
Duodenum / physiology
Eating
Erythromycin / pharmacology
Female
Gastric Emptying / drug effects,  physiology*
Humans
Indium Radioisotopes / diagnostic use
Lipids / pharmacology
Male
Manometry
Regression Analysis
Stomach / drug effects,  physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
RR-00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Indium Radioisotopes; 0/Lipids; 114-07-8/Erythromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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