| Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. | |
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MedLine Citation:
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PMID: 16020106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrointestinal angiodysplasia in association with Bernard-Soulier syndrome has been previously described in adults. The authors report on a 14year-old boy presenting with massive upper gastrointestinal bleeding due to a large gastric angiodysplasia, in whom medical history and laboratory investigations were consistent with Bernard-Soulier syndrome. The vascular lesion was so widespread that surgical or endoscopic therapy was not considered. Therefore, treatment with octreotide, a somatostatin analog, was commenced, following a short course of tranexamic acid and proton pump inhibitor. During the 16-month follow-up with octreotide therapy, no occult or gross bleeding occurred. This case illustrates the utility of using octreotide for the long-term treatment of children with bleeding disorders and angiodysplasia. |
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Authors:
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Zühre Kaya; Türkiz Gürsel; Buket Dalgic; Deniz Aslan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 22 ISSN: 0888-0018 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 2005 Apr-May |
Date Detail:
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Created Date: 2005-07-19 Completed Date: 2005-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: England |
Other Details:
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Languages: eng Pagination: 223-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Angiodysplasia / complications*, diagnosis, drug therapy* Bernard-Soulier Syndrome / complications*, diagnosis, drug therapy* Endoscopy, Gastrointestinal Humans Male Octreotide / administration & dosage, therapeutic use* Stomach Diseases / complications, diagnosis, drug therapy Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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