Document Detail

Gastric adenocarcinoma in a horse with portal vein metastasis and thrombosis: a novel cause of hepatic encephalopathy.
MedLine Citation:
PMID:  16847002     Owner:  NLM     Status:  MEDLINE    
A 17-year-old Quarter horse mare was referred to Cornell University for postmortem examination after 72 hours of encephalopathy that consisted of depression, mania, and blindness. A plasma sample and cerebral spinal fluid demonstrated hyperammonemia. Gross necropsy examination findings included the following: mild icterus, a transmural mass in the glandular portion of the gastric fundus, multiple masses throughout the liver, and a large tumor thrombus in the portal vein. Microscopically, the gastric mass, hepatic masses, and portal vein thrombus were composed of similar neoplastic epithelial cells that formed variably sized acini and branching cords separated by a dense desmoplastic stroma. Throughout the cerebral frontal cortex were numerous Alzheimer type II astrocytes. Hepatic encephalopathy was caused by gastric adenocarcinoma, with metastasis to the liver and the portal vein. The clinical and pathologic lesions from this unique case, as well as hyperammonemia and portal vein thrombosis in the pathogenesis of hepatic encephalopathy, are discussed.
K M Patton; S F Peek; B A Valentine
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  43     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2006-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  IM    
DVM, PhD, L-229 Mosier Hall, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5705 (USA).
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MeSH Terms
Adenocarcinoma / complications,  secondary,  veterinary*
Fatal Outcome
Hepatic Encephalopathy / etiology,  pathology,  veterinary*
Histocytochemistry / veterinary
Horse Diseases / pathology*
Liver Neoplasms / complications,  secondary,  veterinary*
Portal Vein / pathology
Stomach Neoplasms / complications,  pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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